Toxic chemicals from microplastics can be absorbed through skin
Toxic chemicals used to flame-proof plastic materials can be absorbed into the body through skin, via contact with microplastics, new research shows.
Fri, 19 Apr 2024 13:19:01 EDT
https://www.sciencedaily.com/releases/2024/04/240419131901.htm
Warming of Antarctic deep-sea waters contribute to sea level rise in North Atlantic, study finds
Analysis of mooring observations and hydrographic data suggest the Atlantic Meridional Overturning Circulation deep water limb in the North Atlantic has weakened. Two decades of continual observations provide a greater understanding of the Earth's climate regulating system.
Fri, 19 Apr 2024 13:18:07 EDT
https://www.sciencedaily.com/releases/2024/04/240419131807.htm
Octopus inspires new suction mechanism for robots
A new robotic suction cup which can grasp rough, curved and heavy stone, has been developed by scientists.
Thu, 18 Apr 2024 16:52:16 EDT
https://www.sciencedaily.com/releases/2024/04/240418165216.htm
Skyrmions move at record speeds: A step towards the computing of the future
Scientists have discovered that the magnetic nanobubbles known as skyrmions can be moved by electrical currents, attaining record speeds up to 900 m/s. Anticipated as future bits in computer memory, these nanobubbles offer enhanced avenues for information processing in electronic devices. Their tiny size provides great computing and information storage capacity, as well as low energy consumption. Until now, these nanobubbles moved no faster than 100 m/s, which is too slow for computing applications. However, thanks to the use of an antiferromagnetic material as medium, the scientists successfully had the skyrmions move 10 times faster than previously observed. These results offer new prospects for developing higher-performance and less energy-intensive computing devices.
Thu, 18 Apr 2024 16:51:53 EDT
https://www.sciencedaily.com/releases/2024/04/240418165153.htm
One third of China's urban population at risk of city sinking, new satellite data shows
Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.
Thu, 18 Apr 2024 16:51:51 EDT
https://www.sciencedaily.com/releases/2024/04/240418165151.htm
Novel material supercharges innovation in electrostatic energy storage
Scientists have developed artificial heterostructures made of freestanding 2D and 3D membranes that have an energy density up to 19 times higher than commercially available capacitors.
Thu, 18 Apr 2024 16:51:49 EDT
https://www.sciencedaily.com/releases/2024/04/240418165149.htm
A common pathway in the brain that enables addictive drugs to hijack natural reward processing
Researchers have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing systems.
Thu, 18 Apr 2024 16:51:47 EDT
https://www.sciencedaily.com/releases/2024/04/240418165147.htm
Fourteen years after the Gulf of Mexico oil spill, endemic fishes face an uncertain future
The 2010 Gulf of Mexico Deepwater Horizon oil spill, the largest accidental spill in history, released almost 100 million gallons of oil, causing significant pollution. A decade later, its long-term effects remain unclear. A study investigating the impact on endemic fish species found 29 of 78 species unreported in museum collections since the spill, suggesting potential loss of biodiversity.
Thu, 18 Apr 2024 13:27:01 EDT
https://www.sciencedaily.com/releases/2024/04/240418132701.htm
Marine microbial populations: Potential sensors of the global change in the ocean
Animal and plant populations have been extensively studied, which has helped to understand ecosystem processes and evolutionary adaptations. However, this has not been the case with microbial populations due to the impossibility of isolating, culturing and analyzing the genetic content of the different species and their individuals in the laboratory. Therefore, although it is known that populations of microorganisms include a great diversity, this remains largely uncharacterized.
Thu, 18 Apr 2024 13:26:58 EDT
https://www.sciencedaily.com/releases/2024/04/240418132658.htm
Metacognitive abilities like reading the emotions and attitudes of others may be more influenced by environment than genetics
Twin studies have proven invaluable for teasing out the effects of both genetics and the environment on human biology. Researchers studied pairs of twins to look at how the interplay of genetics and environment affect cognitive processing -- the way that people think. They found that some cognitive abilities appear to be regulated more by environmental factors than by genetics.
Thu, 18 Apr 2024 13:26:55 EDT
https://www.sciencedaily.com/releases/2024/04/240418132655.htm
Data-driven music: Converting climate measurements into music
A geo-environmental scientist from Japan has composed a string quartet using sonified climate data. The 6-minute-long composition -- entitled 'String Quartet No. 1 'Polar Energy Budget'-- is based on over 30 years of satellite-collected climate data from the Arctic and Antarctic and aims to garner attention on how climate is driven by the input and output of energy at the poles.
Thu, 18 Apr 2024 11:19:19 EDT
https://www.sciencedaily.com/releases/2024/04/240418111919.htm
Quick decisions in soccer enhanced by brain's ability to suppress actions
Superior decision-making in sports such as soccer could come down to the process of inhibiting a motor response, according to a new study.
Thu, 18 Apr 2024 11:18:23 EDT
https://www.sciencedaily.com/releases/2024/04/240418111823.htm
Perfect balance: How the brain fine-tunes its sensitivity
A sensitive perception of the environment is crucial for guiding our behavior. However, an overly sensitive response of the brain's neural circuits to stimuli can lead to neurodevelopmental disorders such as epilepsy. Researchers now report how neuronal networks in the mouse brain are fine-tuned.
Thu, 18 Apr 2024 11:18:14 EDT
https://www.sciencedaily.com/releases/2024/04/240418111814.htm
Scientists uncover 95 regions of the genome linked to PTSD
In posttraumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person's quality of life. About 6 percent of people who experience trauma develop the disorder, but scientists don't yet understand the neurobiology underlying PTSD. Now, a new genetic study of more than 1.2 million people has pinpointed 95 loci, or locations in the genome, that are associated with risk of developing PTSD, including 80 that had not been previously identified.
Thu, 18 Apr 2024 11:18:11 EDT
https://www.sciencedaily.com/releases/2024/04/240418111811.htm
AI tool predicts responses to cancer therapy using information from each cell of the tumor
Most cancer patients do not benefit from early targeted therapies. Scientists now describe a new computational pipeline to systematically predict patient response to cancer drugs at single-cell resolution.
Thu, 18 Apr 2024 11:18:08 EDT
https://www.sciencedaily.com/releases/2024/04/240418111808.htm
RNA's hidden potential: New study unveils its role in early life and future bioengineering
The origin of life continues to remain a matter of debate. The ribonucleic acid (RNA) world hypothesis proposes that 'ribozymes' which store genetic information and possess catalytic functions may have supported the activities of early life forms. Now, researchers explore how RNA elongation is regulated allosterically, shedding light on its impact on early life processes and offering insights into the fabrication of arbitrary RNA nanostructures with various modern applications.
Thu, 18 Apr 2024 11:18:06 EDT
https://www.sciencedaily.com/releases/2024/04/240418111806.htm
Can bismuth prevent oil leaks?
Companies can't simply walk away from old oil and gas wells. They have to be capped in a way that protects the environment and prevents leaks. A new approach to today's solution could be better for the environment and cheaper, too.
Thu, 18 Apr 2024 11:18:00 EDT
https://www.sciencedaily.com/releases/2024/04/240418111800.htm
How data provided by fitness trackers and smartphones can help people with MS
Monitoring and treating a case of multiple sclerosis requires reliable and long-term data on how the disease is progressing in the person in question. Fitness trackers and smartphones can supply this data, as a research team has now shown.
Thu, 18 Apr 2024 11:17:57 EDT
https://www.sciencedaily.com/releases/2024/04/240418111757.htm
An ink for 3D-printing flexible devices without mechanical joints
Researchers are targeting the next generation of soft actuators and robots with an elastomer-based ink for 3D printing objects with locally changing mechanical properties, eliminating the need for cumbersome mechanical joints.
Thu, 18 Apr 2024 11:17:54 EDT
https://www.sciencedaily.com/releases/2024/04/240418111754.htm
Siblings with unique genetic change help scientists progress drug search for type 1 diabetes
Two siblings who have the only known mutations in a key gene anywhere in the world have helped scientists gain new insights that could help progress the search for new treatments in type 1 diabetes.
Thu, 18 Apr 2024 11:17:49 EDT
https://www.sciencedaily.com/releases/2024/04/240418111749.htm
New urine-based test detects high-grade prostate cancer, helping men avoid unnecessary biopsies
Researchers have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause harm from more aggressive cancer that needs immediate treatment.
Thu, 18 Apr 2024 11:17:44 EDT
https://www.sciencedaily.com/releases/2024/04/240418111744.htm
Study identifies new metric for diagnosing autism
Autism spectrum disorder has yet to be linked to a single cause, due to the wide range of its symptoms and severity. However, a recent study suggests a promising new approach to finding answers, one that could lead to advances in the study of other neurological conditions.
Wed, 17 Apr 2024 18:28:44 EDT
https://www.sciencedaily.com/releases/2024/04/240417182844.htm
Researchers create new AI pipeline for identifying molecular interactions
AI developments in chemical biology could unlock new types of disease treatments.
Wed, 17 Apr 2024 18:28:37 EDT
https://www.sciencedaily.com/releases/2024/04/240417182837.htm
Clearing the air: Wind farms more land efficient than previously thought
Wind power is a source of energy that is both affordable and renewable. However, decision-makers have been reluctant to invest in wind energy due to a perception that wind farms require a lot of land compared to electric power plants driven by fossil fuels. Research was based on the assessment of the land-use of close to 320 wind farms in the U.S. paints a very different picture.
Wed, 17 Apr 2024 18:28:34 EDT
https://www.sciencedaily.com/releases/2024/04/240417182834.htm
Paper: To understand cognition--and its dysfunction--neuroscientists must learn its rhythms
Thought emerges and is controlled in the brain via the rhythmically and spatially coordinated activity of millions of neurons, scientists argue in a new article. Understanding cognition and its disorders requires studying it at that level.
Wed, 17 Apr 2024 18:28:29 EDT
https://www.sciencedaily.com/releases/2024/04/240417182829.htm
Protecting brain cells with cannabinol
Scientists created four cannabis-derived CBN analogs (chemical look-a-likes) with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer's, Parkinson's, and traumatic brain injury. Their findings reveal novel aspects of CBN's neuroprotective activity and demonstrate the clinical potential of CBN and value of studying its analogs.
Wed, 17 Apr 2024 18:28:26 EDT
https://www.sciencedaily.com/releases/2024/04/240417182826.htm
Does using your brain more at work help ward off thinking, memory problems?
The harder your brain works at your job, the less likely you may be to have memory and thinking problems later in life, according to a new study. This study does not prove that stimulating work prevents mild cognitive impairment. It only shows an association.
Wed, 17 Apr 2024 18:28:23 EDT
https://www.sciencedaily.com/releases/2024/04/240417182823.htm
Guidance on energy and macronutrients across the lifespan
In the long history of recommendations for nutritional intake, current research is trending toward the concept of 'food as medicine' -- a philosophy in which food and nutrition are positioned within interventions to support health and wellness.
Wed, 17 Apr 2024 18:28:19 EDT
https://www.sciencedaily.com/releases/2024/04/240417182819.htm
Calorie restriction study reveals complexities in how diet impacts aging
The rate at which human cells age is influenced by multiple interconnected factors. New research examined how restricting calories influences telomere length and biological aging.
Wed, 17 Apr 2024 18:28:16 EDT
https://www.sciencedaily.com/releases/2024/04/240417182816.htm
Atom-by-atom: Imaging structural transformations in 2D materials
Silicon-based electronics are approaching their physical limitations and new materials are needed to keep up with current technological demands. Two-dimensional (2D) materials have a rich array of properties, including superconductivity and magnetism, and are promising candidates for use in electronic systems, such as transistors. However, precisely controlling the properties of these materials is extraordinarily difficult.
Wed, 17 Apr 2024 18:28:13 EDT
https://www.sciencedaily.com/releases/2024/04/240417182813.htm
How 3D printers can give robots a soft touch
Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult to make. A recent study demonstrates that soft skin pads doubling as sensors made from thermoplastic urethane can be efficiently manufactured using 3D printers.
Wed, 17 Apr 2024 18:28:11 EDT
https://www.sciencedaily.com/releases/2024/04/240417182811.htm
Honey bees experience multiple health stressors out-in-the-field
It's not a single pesticide or virus stressing honey bees, and affecting their health, but exposure to a complex web of multiple interacting stressors encountered while at work pollinating crops, found new research. Scientists have been unable to explain increasing colony mortality, even after decades of research examining the role of specific pesticides, parasitic mites, viruses or genetics. This led the research team to wonder if previous studies were missing something by focusing on one stressor at a time.
Wed, 17 Apr 2024 18:28:08 EDT
https://www.sciencedaily.com/releases/2024/04/240417182808.htm
Machine learning used to create a fabric-based touch sensor
A new fabric-based touch sensor used machine learning to control mobile apps, video games and other devices while integrated into clothing.
Wed, 17 Apr 2024 18:27:56 EDT
https://www.sciencedaily.com/releases/2024/04/240417182756.htm
Probiotic feed additive boosts growth, health in poultry in place of antibiotics
The growing need for antibiotic-free products has challenged producers to decrease or completely stop using antimicrobials as feed supplements in the diet of broiler chickens to improve feed efficiency, growth rate and intestinal health. A research team conducted a study of natural feed additives that are promising alternatives to substitute for antimicrobial growth promoters.
Wed, 17 Apr 2024 18:27:53 EDT
https://www.sciencedaily.com/releases/2024/04/240417182753.htm
Global study reveals health impacts of airborne trace elements
Researchers investigated global particulate matter, revealing health risks from trace elements.
Wed, 17 Apr 2024 18:27:48 EDT
https://www.sciencedaily.com/releases/2024/04/240417182748.htm
First evidence of human occupation in lava tube cave in Saudi Arabia
New research has highlighted an area in Arabia that once acted as a key point for cultural exchanges and trades amongst ancient people -- and it all took place in vast caves and lava tubes that have remained largely untapped reservoirs of archaeological abundance in Arabia. Through meticulous excavation and analysis, the international team uncovered a wealth of evidence at Umm Jirsan, spanning from the Neolithic to the Chalcolithic/Bronze Age periods (~10,000-3,500 years ago).
Wed, 17 Apr 2024 18:27:45 EDT
https://www.sciencedaily.com/releases/2024/04/240417182745.htm
New data identifies trends in accidental opioid overdoses in children
The US saw a 22% decline in rates of prescription-opioid overdose related emergency department (ED) visits in children 17 and younger between 2008 and 2019, but an uptick in the early part of the COVID-19 pandemic, according to a new study. The authors also note that rates of pediatric opioid overdoses remain high in many populations.
Wed, 17 Apr 2024 18:27:36 EDT
https://www.sciencedaily.com/releases/2024/04/240417182736.htm
Artificial Intelligence beats doctors in accurately assessing eye problems
A study has found that the AI model GPT-4 significantly exceeds the ability of non-specialist doctors to assess eye problems and provide advice.
Wed, 17 Apr 2024 18:27:12 EDT
https://www.sciencedaily.com/releases/2024/04/240417182712.htm
Ice age climate analysis reduces worst-case warming expected from rising CO2
A detailed reconstruction of climate during the most recent ice age, when a large swath of North America was covered in ice, provides information on the relationship between CO2 and global temperature. Results show that while most future warming estimates remain unchanged, the absolute worst-case scenario is unlikely.
Wed, 17 Apr 2024 18:27:09 EDT
https://www.sciencedaily.com/releases/2024/04/240417182709.htm
East coast mussel shells are becoming more porous in warming waters
Researchers have found that over the last 120 years, the porosity -- or small-scale holes -- in mussel shells along the East Coast of the United States has increased, potentially due to warming waters. The study analyzed modern mussel shells in comparison to specimens in the Museum's historic collection.
Wed, 17 Apr 2024 18:27:06 EDT
https://www.sciencedaily.com/releases/2024/04/240417182706.htm
Researchers find that accelerated aging biology in the placenta contributes to a rare form of pregnancy-related heart failure
In a new study, researchers show that elevated levels of proteins related to cellular senescence, or aging, in the blood and the placenta are linked to this form of heart failure.
Wed, 17 Apr 2024 18:27:03 EDT
https://www.sciencedaily.com/releases/2024/04/240417182703.htm
Paleontologists unearth what may be the largest known marine reptile
The fossilized remains of a second gigantic jawbone measuring more than two meters long has been found on a beach in Somerset, UK.
Wed, 17 Apr 2024 18:26:59 EDT
https://www.sciencedaily.com/releases/2024/04/240417182659.htm
New class of antimicrobials discovered in soil bacteria
Researchers have discovered toxic protein particles, shaped like umbrellas, that soil bacteria known as Streptomyces secrete to squelch competitors in their crowded microbial communities, especially others of their own species. What makes these newly detected antibacterial toxins different is that, unlike the Streptomyces' small-molecule antibiotics, umbrella toxins are large complexes composed of multiple proteins. They are also far more specific in the bacteria they target. They tend to go after bacteria that form branching filaments, an usual growth pattern among bacteria. The scientists are intrigued by the potential clinical clinical applications of this discovery, because they suspect the pathogens that cause tuberculosis and diphtheria might be sensitive to umbrella toxins.
Wed, 17 Apr 2024 13:11:43 EDT
https://www.sciencedaily.com/releases/2024/04/240417131143.htm
38 trillion dollars in damages each year: World economy already committed to income reduction of 19 % due to climate change
Even if CO2 emissions were to be drastically cut down starting today, the world economy is already committed to an income reduction of 19% until 2050 due to climate change, a new study finds. These damages are six times larger than the mitigation costs needed to limit global warming to two degrees. Based on empirical data from more than 1,600 regions worldwide over the past 40 years, scientists assessed future impacts of changing climatic conditions on economic growth and their persistence.
Wed, 17 Apr 2024 13:11:38 EDT
https://www.sciencedaily.com/releases/2024/04/240417131138.htm
Mountain chickadees have remarkable memories. A new study explains why
Mountain chickadees have among the best spatial memory in the animal kingdom. New research identifies the genes at play and offers insight into how a shifting climate may impact the evolution of this unique skill.
Wed, 17 Apr 2024 13:11:36 EDT
https://www.sciencedaily.com/releases/2024/04/240417131136.htm
Understanding climate warming impacts on carbon release from the tundra
The warming climate shifts the dynamics of tundra environments and makes them release trapped carbon, according to a new study published in Nature. These changes could transform tundras from carbon sinks into a carbon source, exacerbating the effects of climate change.
Wed, 17 Apr 2024 13:11:27 EDT
https://www.sciencedaily.com/releases/2024/04/240417131127.htm
Solving a mini mystery of cell division
Trying to hit a target size before dividing seems like the best strategy for maintaining a precise cell size, but bacteria don't do that. Now we know why.
Wed, 17 Apr 2024 13:11:21 EDT
https://www.sciencedaily.com/releases/2024/04/240417131121.htm
Workings of working memory detailed
Investigators have discovered how brain cells responsible for working memory -- the type required to remember a phone number long enough to dial it -- coordinate intentional focus and short-term storage of information.
Wed, 17 Apr 2024 13:11:15 EDT
https://www.sciencedaily.com/releases/2024/04/240417131115.htm
Astronomers uncover methane emission on a cold brown dwarf
Astronomers have discovered methane emission on a brown dwarf, an unexpected finding for such a cold and isolated world. The findings suggest that this brown dwarf might generate aurorae similar to those seen on our own planet as well as on Jupiter and Saturn.
Wed, 17 Apr 2024 13:11:13 EDT
https://www.sciencedaily.com/releases/2024/04/240417131113.htm
Marine plankton behavior could predict future marine extinctions
Marine communities migrated to Antarctica during the Earth's warmest period in 66 million years long before a mass-extinction event.
Wed, 17 Apr 2024 13:11:09 EDT
https://www.sciencedaily.com/releases/2024/04/240417131109.htm
Substantial global cost of climate inaction
Pioneering study reveals that limiting global warming to 1.5 degrees Celsius could reduce the global economic costs of climate change by two thirds. If warming continues to 3 degrees Celsius, global GDP will decrease by up to 10 percent -- with the worst impacts in less developed countries.
Wed, 17 Apr 2024 13:11:03 EDT
https://www.sciencedaily.com/releases/2024/04/240417131103.htm
Plant sensors could act as an early warning system for farmers
Using a pair of sensors made from carbon nanotubes, researchers discovered signals that help plants respond to stresses such as heat, light, or attack from insects or bacteria. Farmers could use these sensors to monitor threats to their crops, allowing them to intervene before the crops are lost.
Wed, 17 Apr 2024 13:10:57 EDT
https://www.sciencedaily.com/releases/2024/04/240417131057.htm
Genetic variant identified that shaped the human skull base
Researchers have identified a variant in the gene TBX1 as key in the development of the unique morphology at the base of the skull. TBX1 is present at higher levels in humans than in closely related hominins. Low TBX1 also occurs in certain genetic conditions causing altered skull base morphology. This study provides a greater understanding of human disease and evolution.
Wed, 17 Apr 2024 13:10:55 EDT
https://www.sciencedaily.com/releases/2024/04/240417131055.htm
From defects to order: Spontaneously emerging crystal arrangements in perovskite halides
A new hybrid layered perovskite featuring elusive spontaneous defect ordering has been found, report scientists. By introducing specific concentrations of thiocyanate ions into FAPbI3 (FA = formamidinium), they observed that ordered columnar defects appeared in the stacked crystalline layers, taking up one-third of the lattice space. These findings could pave the way to an innovative strategy for adjusting the properties of hybrid perovskites, leading to practical advances in optoelectronics and energy generation.
Wed, 17 Apr 2024 13:10:43 EDT
https://www.sciencedaily.com/releases/2024/04/240417131043.htm
'Tube map' around planets and moons made possible by knot theory
Scientists have developed a new method using knot theory to find the optimal routes for future space missions without the need to waste fuel.
Wed, 17 Apr 2024 13:10:41 EDT
https://www.sciencedaily.com/releases/2024/04/240417131041.htm
Spintronics: A new path to room temperature swirling spin textures
In some materials, spins form complex magnetic structures within the nanometer and micrometer scale in which the magnetization direction twists and curls along specific directions. Examples of such structures are magnetic bubbles, skyrmions, and magnetic vortices. Spintronics aims to make use of such tiny magnetic structures to store data or perform logic operations with very low power consumption, compared to today's dominant microelectronic components. However, the generation and stabilization of most of these magnetic textures is restricted to a few materials and achievable under very specific conditions (temperature, magnetic field...). Physicists have now investigated a new approach that can be used to create and stabilize complex spin textures, such as radial vortices, in a variety of compounds.
Wed, 17 Apr 2024 13:10:37 EDT
https://www.sciencedaily.com/releases/2024/04/240417131037.htm
Dog attacks on mountain tapirs highlight a growing threat to endangered wildlife
Researchers who captured footage of dog attacks on endangered mountain tapirs in Colombia are calling for action to protect threatened wildlife.
Wed, 17 Apr 2024 13:10:31 EDT
https://www.sciencedaily.com/releases/2024/04/240417131031.htm
Adults with congenital heart disease faced higher risk of abnormal heart rhythms
Adults with congenital heart defects were more likely to experience an abnormal, irregular heartbeat, finds a new study.
Wed, 17 Apr 2024 13:10:27 EDT
https://www.sciencedaily.com/releases/2024/04/240417131027.htm
A better view with new mid-infrared nanoscopy
A team has constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is typically limited by its low resolution, especially when compared to other microscopy techniques. This latest development produced images at 120 nanometers, which the researchers say is a thirtyfold improvement on the resolution of typical mid-infrared microscopes. Being able to view samples more clearly at this smaller scale can aid multiple fields of research, including into infectious diseases, and opens the way for developing even more accurate mid-infrared-based imaging in the future.
Wed, 17 Apr 2024 13:10:25 EDT
https://www.sciencedaily.com/releases/2024/04/240417131025.htm
Interspecies competition led to even more forms of ancient human -- defying evolutionary trends in vertebrates
Competition between species played a major role in the rise and fall of hominins -- and produced a 'bizarre' evolutionary pattern for the Homo lineage -- according to a new study that revises the start and end dates for many of our early ancestors.
Wed, 17 Apr 2024 13:10:21 EDT
https://www.sciencedaily.com/releases/2024/04/240417131021.htm
