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Gonadal function in male mice disrupted by prenatal risk factors

Researchers have consistently shown that prenatal exposure to Di (2-ethyhexyl) phthalate harms the reproductive system in male mice and causes fertility defects. In a new study, scientists have shown that the combination of DEHP and a high-fat diet in pregnant mice can cause more damage to pups than each factor alone.
Fri, 14 Jun 2024 15:54:34 EDT
https://www.sciencedaily.com/releases/2024/06/240614155434.htm

Scientists solve decades long mystery of NLRC5 sensor function in cell death

A new study identifies NLRC5 as an innate immune sensor that plays a crucial role in PANoptotic cell death -- making it a key therapeutic target.
Fri, 14 Jun 2024 15:53:41 EDT
https://www.sciencedaily.com/releases/2024/06/240614155341.htm

New metric for blood circulation in brain to better understand dementia

Researchers have developed a new metric from measured blood circulation in our brain. This metric has implications for brain conditions, including Alzheimer's disease and other forms of dementia.
Fri, 14 Jun 2024 14:19:23 EDT
https://www.sciencedaily.com/releases/2024/06/240614141923.htm

A new weapon in the battle against antibiotic resistance: Temperature

Scientists have shown in laboratory experiments that an increase in temperature from 37 to 40 degrees Celsius increased the resistance rate for two antimicrobials, while for a third antimicrobial, the higher temperature reduced the resistance rate. If these results can be replicated in human patients, fever control could be a new way to mitigate the emergence of antibiotic resistance.
Fri, 14 Jun 2024 14:19:13 EDT
https://www.sciencedaily.com/releases/2024/06/240614141913.htm

Vitamin B6: New compound delays degradation

A low vitamin B6 level has negative effects on brain performance. A research team has now found a way to delay the degradation of the vitamin.
Fri, 14 Jun 2024 14:19:10 EDT
https://www.sciencedaily.com/releases/2024/06/240614141910.htm

Ultrasensitive liquid biopsy tech spots cancer earlier than standard methods

An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence. The new technology has the potential to improve cancer care with the very early detection of recurrence and close monitoring of tumor response during therapy.
Fri, 14 Jun 2024 14:18:55 EDT
https://www.sciencedaily.com/releases/2024/06/240614141855.htm

Successful trial for new colorectal cancer treatment

Results from a new phase 1 trial indicate that immunotherapy could be used to treat the most common form of colorectal cancer, also known as bowel cancer. Consistent responses to immunotherapy have been reported in patients with the most common type of colorectal tumors, known as MSS mCRC, with 61% of patients seeing their tumor shrink or remain stable after receiving treatment.
Fri, 14 Jun 2024 14:18:52 EDT
https://www.sciencedaily.com/releases/2024/06/240614141852.htm

Study on architecture of heart offers new understanding of human evolution

An international research team has uncovered a new insight into human evolution by comparing humans' hearts with those of other great apes.
Fri, 14 Jun 2024 14:18:49 EDT
https://www.sciencedaily.com/releases/2024/06/240614141849.htm

New approach against fatty liver

Fatty liver disease (steatotic liver disease, SLD for short) is increasingly causing failure of the liver as a vital organ. A team led by researchers has now discovered that a saturated fatty acid in blood vessels leads to the production of the signalling molecule SEMA3A, which closes the 'windows' in the blood vessels. This hinders the transport of fat from the liver to the adipose tissue. The researchers report that the windows open again and the fat in the liver is reduced when SEMA3A is inhibited.
Fri, 14 Jun 2024 14:18:42 EDT
https://www.sciencedaily.com/releases/2024/06/240614141842.htm

New and crucial role discovered for a protein in the body's immunity against cancer

Researchers have found a new function for an existing protein. They discovered that TIMP-1, a protein traditionally known to prevent damage to the body's cells and tissues, plays a critical role in the immune system's defense against cancer. The findings of the study could improve the effectiveness of current cancer immunotherapies.
Fri, 14 Jun 2024 14:18:39 EDT
https://www.sciencedaily.com/releases/2024/06/240614141839.htm

Fasting primes the immune system's natural killer cells to better fight cancer, new study in mice finds

A team of researchers has shown for the first time that fasting can reprogram the metabolism of natural killer cells, helping them to survive in the harsh environment in and around tumors, while also improving their cancer-fighting ability.
Fri, 14 Jun 2024 14:18:27 EDT
https://www.sciencedaily.com/releases/2024/06/240614141827.htm

Infectious H5N1 influenza virus in raw milk rapidly declines with heat treatment

The amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research. However, small, detectable amounts of infectious virus remained in raw milk samples with high virus levels when treated at 72 degrees Celsius (161.6 degrees Fahrenheit) for 15 seconds -- one of the standard pasteurization methods used by the dairy industry. The authors of the study stress, however, that their findings reflect experimental conditions in a laboratory setting and are not identical to large-scale industrial pasteurization processes for raw milk.
Fri, 14 Jun 2024 14:18:22 EDT
https://www.sciencedaily.com/releases/2024/06/240614141822.htm

Novel insights into fluorescent 'dark states' illuminate ways forward for improved imaging

Scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.
Fri, 14 Jun 2024 14:18:19 EDT
https://www.sciencedaily.com/releases/2024/06/240614141819.htm

Global trial confirms benefit of antacids on bleeding prevention for ventilated patients

Critically ill patients are at risk of stress-induced upper gastrointestinal bleeding. Now, a global trial confirms that a widely available drug does prevent upper gastrointestinal bleeding.
Fri, 14 Jun 2024 14:13:23 EDT
https://www.sciencedaily.com/releases/2024/06/240614141323.htm

Low-sodium alternatives can lead to major health gains in Indonesia

Excess sodium intake and a lack of potassium are major contributing factors towards high blood pressure in Indonesia, prompting calls for low-sodium potassium-rich salt substitutes (LSSS) to be readily available to improve health and curb health costs.
Thu, 13 Jun 2024 22:19:26 EDT
https://www.sciencedaily.com/releases/2024/06/240613221926.htm

AI can help doctors make better decisions and save lives

A recent study found that hospitalized patients were 43 percent more likely to have their care escalated and significantly less likely to die if their care team received AI-generated alerts signaling adverse changes in their health.
Thu, 13 Jun 2024 22:19:23 EDT
https://www.sciencedaily.com/releases/2024/06/240613221923.htm

Does exercise in greenspace boost the individual health benefits of each?

Research suggests exercising in a park or other natural setting is more beneficial than exercising indoors.
Thu, 13 Jun 2024 22:19:20 EDT
https://www.sciencedaily.com/releases/2024/06/240613221920.htm

New insights into the brain regions involved in paranoia

The capacity to adjust beliefs about one's actions and their consequences in a constantly changing environment is a defining characteristic of advanced cognition. Disruptions to this ability, however, can negatively affect cognition and behavior, leading to such states of mind as paranoia, or the belief that others intend to harm us. In a new study, scientists uncover how one specific region of the brain might causally provoke these feelings of paranoia. Their novel approach -- which involved aligning data collected from monkeys with human data -- also offers a new cross-species framework through which scientists might better understand human cognition through the study of other species.
Thu, 13 Jun 2024 22:19:18 EDT
https://www.sciencedaily.com/releases/2024/06/240613221918.htm

Can engineered plants help make baby formula as nutritious as breast milk?

New research may help close the nutrition gap between infant formula and human breast milk. The study shows how plants can be programmed to produce a diverse array of beneficial sugars found in human breast milk. The findings could lead to healthier and more affordable formula for babies, or more nutritious non-dairy plant milk for adults.
Thu, 13 Jun 2024 16:11:58 EDT
https://www.sciencedaily.com/releases/2024/06/240613161158.htm

Are mixed emotions real? New research says yes

Neuroscientists found that brains display distinct neural activity when experiencing emotions such as bitter-sweetness. The advance could help solve a longstanding scientific debate: whether 'mixed emotions' arise from unique activity in the brain, or if we're just flip-flopping back and forth between positive and negative feelings.
Thu, 13 Jun 2024 16:11:50 EDT
https://www.sciencedaily.com/releases/2024/06/240613161150.htm

Only one in 20 therapies tested in animals reach approval for human use

An analysis of reviews of translational biomedical research reveals that just 5% of therapies tested in animals reach regulatory approval for human use. The umbrella review summarizes other systematic reviews and provides high level evidence that while the rate of translation to human studies is 50%, there is steep drop off before final approval.
Thu, 13 Jun 2024 16:11:41 EDT
https://www.sciencedaily.com/releases/2024/06/240613161141.htm

Technologies enable 3D imaging of whole human brain hemispheres at subcellular resolution

A suite of three innovations enables high-resolution, high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution. To demonstrate the advance, researchers compared a brain region in an Alzheimer's and a control sample.
Thu, 13 Jun 2024 16:11:38 EDT
https://www.sciencedaily.com/releases/2024/06/240613161138.htm

The yuck factor counteracts sustainable laundry habits

Most people today would lean towards environmentally friendly life choices, but not at the expense of being clean. When it comes to our washing habits, the fear of being perceived as dirty often wins out over the desire to act in an environmentally friendly way. And the more inclined we are to feel disgusted, the more we wash our clothes. This is shown by a unique study that examines the driving forces behind our laundering behaviours and provides new tools for how people's environmental impact can be reduced.
Thu, 13 Jun 2024 16:11:33 EDT
https://www.sciencedaily.com/releases/2024/06/240613161133.htm

The scary, yet promising world of phages, the pathogen's pathogen

Researchers are unlocking the mystery of how bacteria harness viruses to wipe out the competition. The answers could help spur the development of alternatives to antibiotics.
Thu, 13 Jun 2024 16:11:25 EDT
https://www.sciencedaily.com/releases/2024/06/240613161125.htm

Clinical decision support software can prevent 95% of medication errors in the operating room, study shows

Findings indicate that such software can dramatically improve patient safety during surgery.
Thu, 13 Jun 2024 16:02:32 EDT
https://www.sciencedaily.com/releases/2024/06/240613160232.htm

Being given a choice makes touch more pleasant, study finds

When people are asked for consent before being touched, they have a more pleasant experience of the interaction, researchers have discovered.
Thu, 13 Jun 2024 14:09:18 EDT
https://www.sciencedaily.com/releases/2024/06/240613140918.htm

Studies uncover the critical role of sleep in the formation of memories

A lack of sleep can make it extraordinarily difficult to retain information. Two new studies uncover why this is and what is happening inside the brain during sleep and sleep deprivation to help or harm the formation of memories.
Thu, 13 Jun 2024 14:09:06 EDT
https://www.sciencedaily.com/releases/2024/06/240613140906.htm

Short-term loneliness associated with physical health problems

Loneliness may be harmful to our daily health, according to a new study focused on understanding the subtleties of loneliness and how variations in daily feelings of loneliness effect short- and long-term well-being. The researchers said the work provides more evidence in support of the devastating impact of loneliness and isolation on physical health in the country, calling it a public health crisis.
Thu, 13 Jun 2024 14:09:03 EDT
https://www.sciencedaily.com/releases/2024/06/240613140903.htm

Pediatric brain tumors rely on different metabolic 'route' to fuel treatment resistance

Researchers are one step closer to understanding how pediatric DIPG tumors work.
Thu, 13 Jun 2024 14:08:58 EDT
https://www.sciencedaily.com/releases/2024/06/240613140858.htm

Neural balance in the brain is associated with brain maturity and better cognitive ability

The E/I ratio of children decreases with healthy development. Children with a lower E/I ratio were observed to have better performance than their peers in cognitive tests such as memory and intelligence, according to researchers.
Thu, 13 Jun 2024 14:08:49 EDT
https://www.sciencedaily.com/releases/2024/06/240613140849.htm

Parliamentary members use simpler language on hot days

Climate change has many widespread and complicated effects on the well-being of people and the planet, and a new study has now added a surprising one to the list. After analyzing the language used in seven million parliamentary speeches around the world, it shows that high temperatures lead to a significant and immediate reduction in politicians' language complexity.
Thu, 13 Jun 2024 14:08:46 EDT
https://www.sciencedaily.com/releases/2024/06/240613140846.htm

Study hints at tools to prevent diabetes caused by psychiatric meds

New research points to a potential approach to reducing the risk of diabetes associated with widely prescribed antipsychotic medications. The study presents early evidence in support of co-administering antipsychotic medications that block dopamine receptors in the brain alongside drugs that stop antipsychotics from blocking those same receptors in the pancreas. This approach could limit metabolic side effects, including impaired control over blood sugar, or dysglycemia.
Thu, 13 Jun 2024 14:08:40 EDT
https://www.sciencedaily.com/releases/2024/06/240613140840.htm

Confronting trauma alleviates chronic pain among older veterans

A new study found chronic pain among older adults could be significantly reduced through a newly developed psychotherapy that works by confronting past trauma and stress-related emotions that can exacerbate pain symptoms.
Thu, 13 Jun 2024 14:08:35 EDT
https://www.sciencedaily.com/releases/2024/06/240613140835.htm

Reinvigorating exhausted immune cells reveals potential therapy target for cancer

Researchers have not only identified how two immune cells work together to fight cancer but also revealed the cascade of molecules that help coordinate this attack.
Thu, 13 Jun 2024 14:08:27 EDT
https://www.sciencedaily.com/releases/2024/06/240613140827.htm

After major traumatic brain injury, more blood transfusions could mean better outcomes

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life, according to new research.
Thu, 13 Jun 2024 14:08:24 EDT
https://www.sciencedaily.com/releases/2024/06/240613140824.htm

Breakthrough in predicting sudden cardiac death

A new computational method developed by physicists can be used to estimate the risk of sudden cardiac death from a one-minute heart rate measurement at rest. The study was carried out in interdisciplinary collaboration between cardiology and computational physics.
Thu, 13 Jun 2024 14:08:08 EDT
https://www.sciencedaily.com/releases/2024/06/240613140808.htm

Which of the two DNA strands is damaged influences the cell's mutation profile

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals. DNA lesions that persists unrepaired over several cell generations lead to sequence variations at the site of damage, the quantification of which provides insights into the kinetics and mechanisms of DNA repair. This enabled the researchers to distinguish the contribution of the triggering lesion from that of the subsequent repair in shaping the mutation pattern.
Thu, 13 Jun 2024 14:08:02 EDT
https://www.sciencedaily.com/releases/2024/06/240613140802.htm

Promising gene therapy for FOXG1 syndrome

A viral gene therapy has reversed some brain abnormalities in infant mice with FOXG1 syndrome, a significant step toward one day treating children with this severe neurodevelopmental disorder.
Thu, 13 Jun 2024 14:07:43 EDT
https://www.sciencedaily.com/releases/2024/06/240613140743.htm

Why many lung cancer patients who have never smoked have worse outcomes

The reason why targeted treatment for non-small cell lung cancer fails to work for some patients, particularly those who have never smoked, has been discovered.
Thu, 13 Jun 2024 14:05:03 EDT
https://www.sciencedaily.com/releases/2024/06/240613140503.htm

Younger workers feel stressed, lonely and undervalued

Younger workers are struggling with feelings of loneliness and a lack of appreciation at work and tend to feel more comfortable working with people their own age, according to a recent survey.
Thu, 13 Jun 2024 00:14:02 EDT
https://www.sciencedaily.com/releases/2024/06/240613001402.htm

Brain regions that bias the brain's response to pleasure in bipolar disorder identified

Momentary shifts in mood, even those lasting just a matter of seconds, profoundly alter the brain's response to pleasurable experiences in people with bipolar disorder, finds a new study.
Wed, 12 Jun 2024 19:28:47 EDT
https://www.sciencedaily.com/releases/2024/06/240612192847.htm

Risk of secondary cancers after CAR-T cell therapy low, according to large study

In April, the FDA warned of risk of secondary cancers in people receiving CAR-T cell therapy. A large study now finds the risk is low and not related to the CAR-T cells.
Wed, 12 Jun 2024 17:31:22 EDT
https://www.sciencedaily.com/releases/2024/06/240612173122.htm

Does having a child with low birth weight increase a person's risk of dementia?

People who give birth to infants less than 5.5 pounds may be more likely to have memory and thinking problems later in life than people who give birth to infants who do not have a low birth weight, according to a new study. The effect on memory and thinking skills was equivalent to one to two years of aging for those with low-birth-weight deliveries.
Wed, 12 Jun 2024 17:31:16 EDT
https://www.sciencedaily.com/releases/2024/06/240612173116.htm

Depressive symptoms in young adults linked to thinking, memory problems in midlife

People who experience prolonged depressive symptoms starting in young adulthood may have worse thinking and memory skills in middle age, according to a new study. The study also found that depressive symptoms were experienced more often by Black adults than white adults.
Wed, 12 Jun 2024 17:31:13 EDT
https://www.sciencedaily.com/releases/2024/06/240612173113.htm

Exposure to heat and cold in early life may affect development of white matter in the brain

Brain scans of more than 2,000 preadolescents suggests that early life exposure to heat and cold may have lasting effects on the microstructure of white matter in the brain, especially when living in poorer neighborhoods. The study highlights the vulnerability of fetuses and children to extreme temperatures.
Wed, 12 Jun 2024 17:31:10 EDT
https://www.sciencedaily.com/releases/2024/06/240612173110.htm

Swimming microrobots deliver cancer-fighting drugs to metastatic lung tumors in mice

Engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors. This approach has shown promise in mice, where it inhibited the growth and spread of tumors that had metastasized to the lungs, thereby boosting survival rates compared to control treatments.
Wed, 12 Jun 2024 17:31:04 EDT
https://www.sciencedaily.com/releases/2024/06/240612173104.htm

Mouse study identifies unique approach for preventing life-threatening complications after spinal cord injury

A new study identifies a druggable cellular target that, if controlled properly, could prevent or lessen autonomic dysfunction and improve quality of life for people with spinal cord injury.
Wed, 12 Jun 2024 17:28:56 EDT
https://www.sciencedaily.com/releases/2024/06/240612172856.htm

Case study reveals important new details about rare second cancers related to CAR-T therapy

A new detailed analysis of a patient's second cancer after receiving CAR-T therapy for the initial cancer provides rare but important insights intended to offer helpful guidance for oncologists and pathologists about the clinical presentation and pathologic features involved in a CAR-T related second cancer.
Wed, 12 Jun 2024 17:28:07 EDT
https://www.sciencedaily.com/releases/2024/06/240612172807.htm

Mobile monitoring for an airborne carcinogen in Louisiana's 'Cancer Alley'

Louisiana's southeastern corridor is sometimes known colloquially as 'Cancer Alley' for its high cancer incidence rates connected to industrial air pollution. Most of the region's air pollution-related health risks are attributed to ethylene oxide, a volatile compound used to make plastics and sterilize medical equipment. Researchers measured concerning levels of ethylene oxide in this area with mobile optical instruments, a technique they say could improve health risk assessments.
Wed, 12 Jun 2024 14:09:28 EDT
https://www.sciencedaily.com/releases/2024/06/240612140928.htm

Putting the brakes on chronic inflammation

Scientists have discovered a previously unknown link between two key pathways that regulate the immune system in mammals -- a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD). This family of disorders severely impacts the health and quality of life of more than 2 million people in the United States.
Wed, 12 Jun 2024 14:08:52 EDT
https://www.sciencedaily.com/releases/2024/06/240612140852.htm

Incorporating 'touch' into social media interactions can increase feelings of support and approval

Including 'tactile emoticons' into social media communications can enhance communication, according to a new study.
Wed, 12 Jun 2024 14:08:29 EDT
https://www.sciencedaily.com/releases/2024/06/240612140829.htm

The gender gap in life expectancy: Are eggs and sperm partly responsible?

Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.
Wed, 12 Jun 2024 14:08:27 EDT
https://www.sciencedaily.com/releases/2024/06/240612140827.htm

'Synthetic' cell shown to follow chemical directions and change shape, a vital biological function

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called 'symmetry breaking.'
Wed, 12 Jun 2024 14:08:21 EDT
https://www.sciencedaily.com/releases/2024/06/240612140821.htm

To heal skin, scientists invent living bioelectronics

Engineers have created a patch that combines sensors and bacteria to interact with the body.
Wed, 12 Jun 2024 14:08:15 EDT
https://www.sciencedaily.com/releases/2024/06/240612140815.htm

Robot radiotherapy could improve treatments for eye disease

Researchers have successfully used a new robot system to improve treatment for debilitating eye disease.
Wed, 12 Jun 2024 11:33:53 EDT
https://www.sciencedaily.com/releases/2024/06/240612113353.htm

Towards a new era in flexible piezoelectric sensors for both humans and robots

Flexible piezoelectric sensors are essential to monitor the motions of both humans and humanoid robots. However, existing designs are either are costly or have limited sensitivity. In a recent study, researchers tackled these issues by developing a novel piezoelectric composite material made from electrospun polyvinylidene fluoride nanofibers combined with dopamine. Sensors made from this material showed significant performance and stability improvements at a low cost, promising advancements in medicine, healthcare, and robotics.
Wed, 12 Jun 2024 11:33:43 EDT
https://www.sciencedaily.com/releases/2024/06/240612113343.htm

AI better detects prostate cancer on MRI than radiologists

AI detects prostate cancer more often than radiologists. Additionally, AI triggers false alarms half as often. This was a large-scale study where an international team transparently evaluated and compared AI with radiologist assessments and clinical outcomes.
Wed, 12 Jun 2024 11:33:41 EDT
https://www.sciencedaily.com/releases/2024/06/240612113341.htm

Age is just a number: Immune cell 'epigenetic clock' ticks independently of organism lifespan

Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.
Wed, 12 Jun 2024 11:33:31 EDT
https://www.sciencedaily.com/releases/2024/06/240612113331.htm

Site new care homes near trees and away from busy roads to protect residents' lungs

To shield older residents from dangerous air pollution, new care homes should be built as far from heavy traffic as possible, according to a new study.
Wed, 12 Jun 2024 11:33:29 EDT
https://www.sciencedaily.com/releases/2024/06/240612113329.htm

Nasal microbiota is potential diagnostic biomarker for sepsis

A new study shows that analyzing nasal microbiota outperforms gut microbiota analysis to predict sepsis in the ICU.
Wed, 12 Jun 2024 11:33:11 EDT
https://www.sciencedaily.com/releases/2024/06/240612113311.htm


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