Breast cancer rates rising among Canadian women in their 20s, 30s and 40s
Rates of breast cancer in women under the age of 50 are rising in Canada according to a study which showed an increase in breast cancer diagnoses among females in their twenties, thirties, and forties.
Fri, 26 Apr 2024 16:52:27 EDT
https://www.sciencedaily.com/releases/2024/04/240426165227.htm
Florida dolphin found with highly pathogenic avian flu
Report details first-ever finding of highly pathogenic avian influenza virus in North American dolphin.
Fri, 26 Apr 2024 16:51:59 EDT
https://www.sciencedaily.com/releases/2024/04/240426165159.htm
How geography acts as a structural determinant of health
In unincorporated communities in the United States-Mexico borderlands, historically and socially marginalized populations become invisible to the healthcare system, showing that geography acts as a structural determinant of health for low-income populations.
Fri, 26 Apr 2024 16:51:44 EDT
https://www.sciencedaily.com/releases/2024/04/240426165144.htm
Getting dynamic information from static snapshots
Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Fri, 26 Apr 2024 16:51:42 EDT
https://www.sciencedaily.com/releases/2024/04/240426165142.htm
Automated machine learning robot unlocks new potential for genetics research
Researchers have constructed a robot that uses machine learning to fully automate a complicated microinjection process used in genetic research.
Fri, 26 Apr 2024 11:00:57 EDT
https://www.sciencedaily.com/releases/2024/04/240426110057.htm
Air pollution and depression linked with heart disease deaths in middle-aged adults
A study in more than 3,000 US counties, with 315 million residents, has suggested that air pollution is linked with stress and depression, putting under-65-year-olds at increased risk of dying from cardiovascular disease.
Fri, 26 Apr 2024 11:00:54 EDT
https://www.sciencedaily.com/releases/2024/04/240426110054.htm
Climb stairs to live longer
Climbing stairs is associated with a longer life, according to new research
Fri, 26 Apr 2024 11:00:51 EDT
https://www.sciencedaily.com/releases/2024/04/240426110051.htm
Illusion helps demystify the way vision works
Research shows that a certain kind of visual illusion, neon color spreading, works on mice. The study is also the first to combine the use of two investigative techniques called electrophysiology and optogenetics to study this illusion. Results from experiments on mice settle a long-standing debate in neuroscience about which levels of neurons within the brain are responsible for the perception of brightness.
Fri, 26 Apr 2024 11:00:25 EDT
https://www.sciencedaily.com/releases/2024/04/240426110025.htm
Robotic nerve 'cuffs' could help treat a range of neurological conditions
Researchers have developed tiny, flexible devices that can wrap around individual nerve fibers without damaging them. The researchers combined flexible electronics and soft robotics techniques to develop the devices, which could be used for the diagnosis and treatment of a range of disorders, including epilepsy and chronic pain, or the control of prosthetic limbs.
Fri, 26 Apr 2024 11:00:20 EDT
https://www.sciencedaily.com/releases/2024/04/240426110020.htm
Using stem cell-derived heart muscle cells to advance heart regenerative therapy
Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles. The highly positive outcomes observed in primate models highlight the potential of this strategy.
Fri, 26 Apr 2024 11:00:17 EDT
https://www.sciencedaily.com/releases/2024/04/240426110017.htm
Advance in the treatment of acute heart failure identified
A multicenter study has identified a potential new treatment for acute heart failure, a leading cause of hospitalization and death.
Thu, 25 Apr 2024 16:15:52 EDT
https://www.sciencedaily.com/releases/2024/04/240425161552.htm
Early trauma cuts life short for squirrels, and climate change could make matters worse
Life can be tough for young red squirrels living in the Canada's Yukon territory, where frigid winters, food scarcity and predators threaten their long-term survival. Scientists want to know what factors might protect young squirrels, especially as their environment becomes more impacted by climate change.
Thu, 25 Apr 2024 16:15:49 EDT
https://www.sciencedaily.com/releases/2024/04/240425161549.htm
RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease
A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.
Thu, 25 Apr 2024 16:15:29 EDT
https://www.sciencedaily.com/releases/2024/04/240425161529.htm
Shoulder surgeons should rethink a common practice, study suggests
Many surgeons remove the bursa when repairing rotator cuff injuries, but a new animal study suggests that the small tissue helps with healing.
Thu, 25 Apr 2024 16:15:23 EDT
https://www.sciencedaily.com/releases/2024/04/240425161523.htm
Vitamin D alters mouse gut bacteria to give better cancer immunity
Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.
Thu, 25 Apr 2024 16:15:12 EDT
https://www.sciencedaily.com/releases/2024/04/240425161512.htm
Food in sight? The liver is ready!
What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
Thu, 25 Apr 2024 16:15:04 EDT
https://www.sciencedaily.com/releases/2024/04/240425161504.htm
Treatment for deadly superbug C. diff may be weakening
The antibiotic vancomycin, recommended as first-line treatment for infection caused by the deadly superbug C. difficile (C. diff), may not be living up to its promise, according to new research.
Thu, 25 Apr 2024 13:16:03 EDT
https://www.sciencedaily.com/releases/2024/04/240425131603.htm
Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Thu, 25 Apr 2024 13:15:49 EDT
https://www.sciencedaily.com/releases/2024/04/240425131549.htm
Identifying a new liver defender: The role of resident macrophages
Researchers discovered liver resident macrophages' pivotal role in defending against gut bacteria and related substances entering via the portal vein, particularly under compromised intestinal barrier conditions. Identified as 'sentinel macrophages,' they are activated by isoallo-lithocholic acid. This finding holds promise for developing preventive and therapeutic strategies for liver chronic inflammatory diseases, such as metabolic dysfunction-associated steatohepatitis (MASH), by enhancing the function of these macrophages to mitigate inflammation and improve treatment efficacy.
Thu, 25 Apr 2024 13:15:00 EDT
https://www.sciencedaily.com/releases/2024/04/240425131500.htm
Diamond dust shines bright in Magnetic Resonance Imaging
An unexpected discovery surprised a scientist: nanometer-sized diamond particles, which were intended for a completely different purpose, shone brightly in a magnetic resonance imaging experiment -- much brighter than the actual contrast agent, the heavy metal gadolinium. Could diamond dust -- in addition to its use in drug delivery to treat tumor cells -- one day become a novel contrast agent used for MRI?
Thu, 25 Apr 2024 13:14:43 EDT
https://www.sciencedaily.com/releases/2024/04/240425131443.htm
Physical activity in nature helps prevent several diseases, including depression and type 2 diabetes
Physical activity in natural environments prevent almost 13,000 cases of non-communicable diseases a year in England and save treatment costs of more than 100 million, new research has found.
Thu, 25 Apr 2024 13:14:40 EDT
https://www.sciencedaily.com/releases/2024/04/240425131440.htm
Genetic variations may predispose people to Parkinson's disease following long-term pesticide exposure, study finds
A new study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.
Thu, 25 Apr 2024 13:14:37 EDT
https://www.sciencedaily.com/releases/2024/04/240425131437.htm
Simplified diagnosis of rare eye diseases
Uveitis is a rare inflammatory eye disease. Posterior and panuveitis in particular are associated with a poor prognosis and a protracted course of the disease. Diagnosis and monitoring can be challenging for healthcare professionals. Fundus autofluorescence (FAF) is a fast and non-invasive imaging technique that supports this. Researchers have drafted a review on how FAF can facilitate the diagnosis and monitoring of posterior uveitis and panuveitis.
Thu, 25 Apr 2024 13:14:31 EDT
https://www.sciencedaily.com/releases/2024/04/240425131431.htm
AI in medicine: The causality frontier
Machines can learn not only to make predictions, but also to handle causal relationships. An international research team shows how this could make therapies safer, more efficient, and more individualized.
Thu, 25 Apr 2024 13:14:08 EDT
https://www.sciencedaily.com/releases/2024/04/240425131408.htm
How electric vehicle drivers can escape range anxiety
Two of the biggest challenges faced by new and potential electric vehicle (EV) drivers are range anxiety and speed of charging, but these shouldn't have to be challenges at all. Researchers discovered that a change in refueling mindset, rather than improving the size or performance of the battery, could be the answer to these concerns.
Thu, 25 Apr 2024 13:14:02 EDT
https://www.sciencedaily.com/releases/2024/04/240425131402.htm
Advanced cell atlas opens new doors in biomedical research
Researchers have developed a web-based platform that offers an unprecedented view of the human body at the cellular level. The aim is to create an invaluable resource for researchers worldwide to increase knowledge about human health and disease.
Thu, 25 Apr 2024 13:13:51 EDT
https://www.sciencedaily.com/releases/2024/04/240425131351.htm
Using AI to improve diagnosis of rare genetic disorders
Diagnosing rare Mendelian disorders is a labor-intensive task, even for experienced geneticists. Investigators are trying to make the process more efficient using artificial intelligence. The team developed a machine learning system called AI-MARRVEL (AIM) to help prioritize potentially causative variants for Mendelian disorders.
Thu, 25 Apr 2024 13:13:45 EDT
https://www.sciencedaily.com/releases/2024/04/240425131345.htm
Maternal grandmothers' support buffers children against the impacts of adversity
A study shows that investment by maternal grandmothers can improve the well-being of grandchildren who have faced adversities in life. The positive effects can last well into adulthood.
Thu, 25 Apr 2024 13:13:39 EDT
https://www.sciencedaily.com/releases/2024/04/240425131339.htm
Circadian rhythms can influence drugs' effectiveness
Researchers discovered that more than 300 liver genes are under circadian control: Circadian variations affect how much of a drug is available and how effectively the body can break it down.
Thu, 25 Apr 2024 13:13:36 EDT
https://www.sciencedaily.com/releases/2024/04/240425131336.htm
How immune cells communicate to fight viruses
Chemokines are signalling proteins that orchestrate the interaction of immune cells against pathogens and tumors. To understand this complex network, various techniques have been developed to identify chemokine-producing cells. However, it has not yet been possible to determine which cells react to these chemokines. Researchers have now developed a new class of genetically modified mice that enables the simultaneous identification of chemokine producers and sensors.
Thu, 25 Apr 2024 13:13:31 EDT
https://www.sciencedaily.com/releases/2024/04/240425131331.htm
National trial safely scaled back prescribing of a powerful antipsychotic for the elderly
Warning letters can safely cut prescribing of a powerful but risky antipsychotic, according to a new study. Researchers used Medicare data to study the effects of the letters on hundreds of thousands of older adults with dementia. They found a significant and lasting reduction in prescribing but no signs of adverse effects on patient health.
Thu, 25 Apr 2024 13:13:21 EDT
https://www.sciencedaily.com/releases/2024/04/240425131321.htm
Solving the riddle of the sphingolipids in coronary artery disease
Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.
Wed, 24 Apr 2024 18:25:01 EDT
https://www.sciencedaily.com/releases/2024/04/240424182501.htm
Use of acid reflux drugs linked to higher risk of migraine
People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.
Wed, 24 Apr 2024 18:24:53 EDT
https://www.sciencedaily.com/releases/2024/04/240424182453.htm
A closed-loop drug-delivery system could improve chemotherapy
To improve chemotherapy dosing, engineers designed CLAUDIA, a way to continuously measure how much drug is in a patient's system during hours-long infusion.
Wed, 24 Apr 2024 18:24:47 EDT
https://www.sciencedaily.com/releases/2024/04/240424182447.htm
Tumor cells evade the immune system early on: Newly discovered mechanism could significantly improve cancer immunotherapies
Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers have now uncovered for the first time how this exactly happens. The study provides rationales for new cancer immunotherapies and could make existing treatments more effective.
Wed, 24 Apr 2024 16:06:47 EDT
https://www.sciencedaily.com/releases/2024/04/240424160647.htm
Mini-colons revolutionize colorectal cancer research
In a breakthrough for cancer research, scientists have created lab-grown mini-colons that can accurately mimic the development of colorectal tumors, offering a powerful new tool for studying and testing treatments for the disease.
Wed, 24 Apr 2024 16:06:37 EDT
https://www.sciencedaily.com/releases/2024/04/240424160637.htm
Artificial intelligence can develop treatments to prevent 'superbugs'
Cleveland Clinic researchers developed an artficial intelligence (AI) model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based solely on how quickly the bacteria grow given certain perturbations. PNAS recently published their findings.
Wed, 24 Apr 2024 16:06:25 EDT
https://www.sciencedaily.com/releases/2024/04/240424160625.htm
After spinal cord injury, neurons wreak havoc on metabolism
Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.
Wed, 24 Apr 2024 16:05:42 EDT
https://www.sciencedaily.com/releases/2024/04/240424160542.htm
Network model unifies recency and central tendency biases
Neuroscientists have revealed that recency bias in working memory naturally leads to central tendency bias, the phenomenon where people's (and animals') judgements are biased towards the average of previous observations. Their findings may hint at why the phenomenon is so ubiquitous.
Wed, 24 Apr 2024 16:05:39 EDT
https://www.sciencedaily.com/releases/2024/04/240424160539.htm
Scientists identify and show how to target a key tumor defense against immune attack
A new study has discovered how a lipid molecule found at high levels within tumors undermines the anti-cancer immune response and compromises a recently approved immunotherapy known as adoptive cell therapy (ACT) using tumor infiltrating lymphocytes, or TIL-ACT.
Wed, 24 Apr 2024 16:05:37 EDT
https://www.sciencedaily.com/releases/2024/04/240424160537.htm
Can climate change accelerate transmission of malaria? Pioneering research sheds light on impacts of temperature
A groundbreaking study combined novel experimental data within an innovative modeling framework to examine how temperature might affect transmission risk of malaria in different environments in Africa.
Wed, 24 Apr 2024 16:05:05 EDT
https://www.sciencedaily.com/releases/2024/04/240424160505.htm
Cells may possess hidden communication system
Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.
Wed, 24 Apr 2024 16:04:54 EDT
https://www.sciencedaily.com/releases/2024/04/240424160454.htm
A flexible microdisplay can monitor brain activity in real-time during brain surgery
A thin film that combines an electrode grid and LEDs can both track and produce a visual representation of the brain's activity in real-time during surgery -- a huge improvement over the current state of the art. The device is designed to provide neurosurgeons visual information about a patient's brain to monitor brain states during surgical interventions to remove brain lesions including tumors and epileptic tissue.
Wed, 24 Apr 2024 16:02:44 EDT
https://www.sciencedaily.com/releases/2024/04/240424160244.htm
A university lecture, with a dash of jumping jacks
A university professor has found a way to help students -- and himself -- power through long lecture classes: exercise breaks. A new study showed that five-minute exercise sessions during lectures were feasible and that students reported positive impacts on their attention and motivation, engagement with their peers and course enjoyment.
Wed, 24 Apr 2024 16:02:28 EDT
https://www.sciencedaily.com/releases/2024/04/240424160228.htm
Survey finds loneliness epidemic runs deep among parents
A new national survey finds a broad majority of parents experience isolation, loneliness and burnout from the demands of parenthood, with many feeling a lack of support in fulfilling that role.
Wed, 24 Apr 2024 11:17:13 EDT
https://www.sciencedaily.com/releases/2024/04/240424111713.htm
Unveiling the mysteries of cell division in embryos with timelapse photography
The beginning of life is shrouded in mystery. While the intricate dynamics of mitosis is well-studied in the so-called somatic cells -- the cells that have a specialized function, like skin and muscle cells -- they remain elusive in the first cells of our bodies, the embryonic cells. Embryonic mitosis is notoriously difficult to study in vertebrates, as live functional analyses and -imaging of experimental embryos are technically limited, which makes it hard to track cells during embryogenesis.
Wed, 24 Apr 2024 11:17:01 EDT
https://www.sciencedaily.com/releases/2024/04/240424111701.htm
Good heart health in middle age may preserve brain function among Black women as they age
Cognitive decline among Black women linked to poor heart health in middle age.
Wed, 24 Apr 2024 11:16:56 EDT
https://www.sciencedaily.com/releases/2024/04/240424111656.htm
AI designs new drugs based on protein structures
A new computer process makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionize drug research.
Wed, 24 Apr 2024 11:16:53 EDT
https://www.sciencedaily.com/releases/2024/04/240424111653.htm
Neurons spoil your appetite
A brain circuit inhibits food intake during nausea.
Wed, 24 Apr 2024 11:16:41 EDT
https://www.sciencedaily.com/releases/2024/04/240424111641.htm
New research shows 'profound' link between dietary choices and brain health
New research has highlighted the profound link between dietary choices and brain health.
Wed, 24 Apr 2024 11:16:38 EDT
https://www.sciencedaily.com/releases/2024/04/240424111638.htm
It takes two to TANGO: New strategy to tackle fibrosis and scarring
A study has now successfully controlled the effects of collagen hypersecretion at the cellular level. The experimental treatment consists of designer peptides which interrupt the interaction between TANGO1 and cTAGE5, two proteins important for collagen secretion. Experiments with patient-derived human cells and zebrafish showed the peptides are effective, non-toxic, and their effects reversible. The results pave the way for the development of new treatments that improve the cosmetic effects of scarring, relieve the symptoms of autoimmune diseases such as scleroderma, or help prevent the development of fibrosis, a more serious condition attributed to 45% of deaths in the industrialized world.
Wed, 24 Apr 2024 11:16:32 EDT
https://www.sciencedaily.com/releases/2024/04/240424111632.htm
CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in phase I trial
Researchers have published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas.
Wed, 24 Apr 2024 11:16:24 EDT
https://www.sciencedaily.com/releases/2024/04/240424111624.htm
Social change may explain decline in genetic diversity of the Y chromosome at the end of the Neolithic period
The emergence in the Neolithic of patrilineal social systems, in which children are affiliated with their father's lineage, may explain a spectacular decline in the genetic diversity of the Y chromosome observed worldwide between 3,000 and 5,000 years ago.
Wed, 24 Apr 2024 11:16:21 EDT
https://www.sciencedaily.com/releases/2024/04/240424111621.htm
Social media can be used to increase fruit and vegetable intake in young people
Researchers have found that people following healthy eating accounts on social media for as little as two weeks ate more fruit and vegetables and less junk food.
Wed, 24 Apr 2024 11:16:18 EDT
https://www.sciencedaily.com/releases/2024/04/240424111618.htm
A vaccine to fight antibiotic resistance
Researchers have created a new vaccine candidate to treat staph and MRSA infections.
Wed, 24 Apr 2024 11:16:15 EDT
https://www.sciencedaily.com/releases/2024/04/240424111615.htm
Low intensity exercise linked to reduced depression
New research has found a significant association between participating in low to moderate intensity exercise and reduced rates of depression.
Wed, 24 Apr 2024 11:16:12 EDT
https://www.sciencedaily.com/releases/2024/04/240424111612.htm
Positive effect of midazolam after cardiac arrest
If a patient is successfully resuscitated after a cardiac arrest and circulation resumes, they are not out of the woods yet. A number of factors can influence whether and how they survive the trauma in the subsequent phase. The administration of the anaesthetic midazolam has a positive effect, as shown by a multicenter study of 571 patients.
Wed, 24 Apr 2024 11:16:09 EDT
https://www.sciencedaily.com/releases/2024/04/240424111609.htm
Computer game in school made students better at detecting fake news
A computer game helped upper secondary school students become better at distinguishing between reliable and misleading news.
Wed, 24 Apr 2024 11:16:04 EDT
https://www.sciencedaily.com/releases/2024/04/240424111604.htm
Researchers unveil PI3K enzyme's dual accelerator and brake mechanisms
The enzyme PI3K plays a critical role in cell migration. Scientists have long understood this function. But researchers have recently unveiled that a subunit of this enzyme also has the ability to slam on the breaks to this process.
Wed, 24 Apr 2024 11:16:01 EDT
https://www.sciencedaily.com/releases/2024/04/240424111601.htm
Biophysics: Testing how well biomarkers work
Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
Wed, 24 Apr 2024 11:15:36 EDT
https://www.sciencedaily.com/releases/2024/04/240424111536.htm
