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Economic burden of childhood verbal abuse by adults estimated at $300 billion globally

Childhood verbal abuse by adults costs society an estimated $300 billion a year globally, show recent findings.
Thu, 11 Apr 2024 13:03:22 EDT

Parkinson's Disease: New theory on the disease's origins and spread

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.
Thu, 11 Apr 2024 13:01:49 EDT

Synthetic platelets stanch bleeding, promote healing in animal models

Researchers have developed synthetic platelets that can be used to stop bleeding and enhance healing at the site of an injury. The researchers have demonstrated that the synthetic platelets work well in animal models but have not yet begun clinical trials in humans.
Thu, 11 Apr 2024 13:01:41 EDT

Study lays the basis for new knowledge on gastrointestinal diseases

The transition from the esophagus to the stomach is a delicate region from a medical point of view, often associated with pathological disorders leading to cancer. An international research team has now gained new insights into this region. These pave the way for new prevention and treatment options.
Thu, 11 Apr 2024 13:01:36 EDT

Chemicals stored in home garages linked to ALS risk

Storing chemicals in a garage at home may associate with an increased risk of ALS, a study finds. This comes as research has found that exposure to environmental toxins, such as pesticides and volatile organic compounds, are also linked to ALS development. Researchers call the buildup of exposures of the lifetime the ALS exposome.
Thu, 11 Apr 2024 13:01:30 EDT

In the drive to deprescribe, heartburn drug study teaches key lessons

One of the largest-ever studies on the topic of deprescribing medications shows the potential promise, and pitfalls, of a massive effort to reduce overuse of a common class of heartburn medications known as proton pump inhibitors or PPIs. It also reveals that some of the feared risks from PPIs may be overblown.
Thu, 11 Apr 2024 13:01:28 EDT

People who use willpower alone to achieve goals, resist temptation, deemed more trustworthy

People who use willpower to overcome temptations and achieve their goals are perceived as more trustworthy than those who use strategies that involve external incentives or deterrents -- such as swear jars or internet-blocking apps -- according to new research.
Thu, 11 Apr 2024 13:01:19 EDT

This outdated diabetes drug still has something to offer

Researchers have discovered the biochemical workings of an old-fashioned diabetes drug, and it's helping them develop new, safer alternatives.
Thu, 11 Apr 2024 13:01:16 EDT

Safety of a potential new treatment to manage complications from sickle cell disease

A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study. An early phase randomized clinical trial involving 130 patients with sickle cell disease found that the drug, called riociguat, was found to be safe to use and well tolerated in these patients and significantly improved their blood pressure. Preliminary efficacy data suggested the medication might improve heart function.
Thu, 11 Apr 2024 13:01:11 EDT

Hypertensive disorders of pregnancy increase risk of cardiovascular death after giving birth

Health researchers identify patients at risk for preventable death in the year after pregnancy.
Thu, 11 Apr 2024 13:01:09 EDT

Newly found genetic variant defends against Alzheimer's disease

Neuroscientists have identified a genetic mutation that fends off Alzheimer's disease in people at high risk and could lead to a new way to protect people from the disease.
Wed, 10 Apr 2024 16:15:55 EDT

New way to generate human cartilage

University of Montana researchers and their partners have found a new method to generate human cartilage of the head and neck.
Wed, 10 Apr 2024 16:15:47 EDT

New origin of deep brain waves discovered

Biomedical engineering researchers have uncovered a previously unknown source of two key brain waves crucial for deep sleep: slow waves and sleep spindles. Traditionally believed to originate from one brain circuit linking the thalamus and cortex, the team's findings suggest that the axons in memory centers of the hippocampus play a role.
Wed, 10 Apr 2024 16:15:44 EDT

More than half a million global stroke deaths may be tied to climate change

A changing climate may be linked to growing death and disability from stroke in regions around the world, according to a new study. Researchers found over three decades that non-optimal temperatures, those above or below temperatures associated with the lowest death rates, were increasingly linked to death and disability due to stroke. The study does not prove that climate change causes stroke. It only shows an association. The study also did not examine other risk factors such as high blood pressure and high cholesterol levels.
Wed, 10 Apr 2024 16:15:19 EDT

Mixed diets balance nutrition and carbon footprint

What we eat can impact our health as well as the environment. Many studies have looked at the impacts of diets in very general terms focused at the level of food groups. A new study explores this issue following a more nuanced dish-level approach. One of the benefits of this kind of study is that people's connections with their diets vary around the world and have strong cultural associations. Knowledge of the impacts of diets using dishes rather than broad food groups can help individuals make informed choices and those in the food industry improve their practices.
Wed, 10 Apr 2024 16:14:50 EDT

AI powered 'digital twin' models the infant microbiome

Researchers have developed a new generative artificial intelligence (AI) tool that models the infant microbiome. This 'digital twin' of the infant microbiome creates a virtual model that predicts the changing dynamics of microbial species in the gut, and how they change as the infant develops.
Wed, 10 Apr 2024 16:14:45 EDT

Size of salty snack influences eating behavior that determines amount consumed

The size of an individual snack piece not only influences how fast a person eats it, but also how much of it they eat, according to a new study. With nearly a quarter of daily calorie intake in the United States coming from snacks, these findings may have implications for helping people better understand how eating behavior impacts calorie and sodium intake.
Wed, 10 Apr 2024 16:14:37 EDT

How the body switches out of 'fight' mode

Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions. But previously, astonishingly little was known about how they exactly do that. Researchers have now explored the molecular mechanism of action in greater detail. As the researchers report, glucocorticoids reprogram the metabolism of immune cells, activating the body's natural 'brakes' on inflammation. These findings lay the groundwork for development of anti-inflammatory agents with fewer and less severe side effects.
Wed, 10 Apr 2024 12:56:36 EDT

New drug prevents flu-related inflammation and lung damage

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
Wed, 10 Apr 2024 12:56:20 EDT

Researchers identify protein that controls CAR T cell longevity

CAR T cell therapy has revolutionized the way certain types of cancer are treated, and the longer those CAR T cells live in a patient's body, the more effectively they respond to cancer. Now, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers.
Wed, 10 Apr 2024 12:56:12 EDT

The genesis of our cellular skeleton, image by image

Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.
Wed, 10 Apr 2024 12:56:07 EDT

Researchers discover how we perceive bitter taste

A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.
Wed, 10 Apr 2024 11:28:24 EDT

Does the time of day you move your body make a difference to your health?

Undertaking the majority of daily physical activity in the evening is linked to the greatest health benefits for people living with obesity, according to researchers who followed the trajectory of 30,000 people over almost 8 years.
Wed, 10 Apr 2024 11:27:56 EDT

Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered

Over 12 million people worldwide suffer from a chronic infection with the hepatitis D virus. This most severe viral liver disease is associated with a high risk of dying from liver cirrhosis and liver cancer. It is caused by the hepatitis D virus (HDV), which uses the surface proteins of the hepatitis B virus (HBV) as a vehicle to specifically enter liver cells via a protein in the cell membrane -- the bile salt transporter protein NTCP.
Wed, 10 Apr 2024 11:27:45 EDT

New insight into combating drug-resistant prostate cancer

New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the activity of coregulator proteins.
Wed, 10 Apr 2024 11:27:42 EDT

A promising target for new RNA therapeutics now accessible

Only recently, a new era in medicine began with the first RNA vaccines. These active substances are modified RNAs that trigger immune responses of the human immune system. Another approach in RNA medicine targets the body's own RNA and its protein modulators by specifically tailored active substances.
Wed, 10 Apr 2024 11:27:34 EDT

Obese and overweight children at risk of iron deficiency

Children and young people who are overweight or obese are at significantly higher risk of iron deficiency, according to a study by nutritional scientists.
Wed, 10 Apr 2024 11:27:26 EDT

AI makes retinal imaging 100 times faster, compared to manual method

Researchers applied artificial intelligence (AI) to a technique that produces high-resolution images of cells in the eye. They report that with AI, imaging is 100 times faster and improves image contrast 3.5-fold. The advance, they say, will provide researchers with a better tool to evaluate age-related macular degeneration (AMD) and other retinal diseases.
Wed, 10 Apr 2024 11:27:20 EDT

Impact of aldehydes on DNA damage and aging

Researchers have discovered the connection between aldehydes, organic compounds produced by cells as part of metabolic processes, and rapid aging. Their findings indicate a potential treatment for diseases that lead to accelerated aging as well as a means to counteract aging in healthy people by controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.
Wed, 10 Apr 2024 11:27:17 EDT

Scientists identify pro-aging 'sugar signature' in the blood of people living with HIV

Scientists have identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV.
Wed, 10 Apr 2024 11:27:06 EDT

Revascularization enhances quality of life for patients with chronic limb threatening ischemia

Over 200 million people around the world experience peripheral artery disease (PAD) -- a condition caused by the narrowing of the blood vessels from the heart to the lower limbs that leads to pain when walking -- and for roughly 1-in-10 this advances to chronic limb-threatening ischemia (CLTI), an advanced form of PAD. Those with CLTI often suffer severe pain even at rest, caused by fatty plaque buildup obstructing blood flow, typically to the leg or foot.
Wed, 10 Apr 2024 11:26:51 EDT

A new screening protocol can detect aggressive prostate cancers more selectively

A large randomized trial shows that a new three-step prostate cancer screening method can find a considerable number of aggressive cancers. Population-level screening programs have not been launched in most countries.
Wed, 10 Apr 2024 11:26:48 EDT

Research uncovers differences between men and women in sleep, circadian rhythms and metabolism

A new review of research evidence has explored the key differences in how women and men sleep, variations in their body clocks, and how this affects their metabolism.
Wed, 10 Apr 2024 11:26:43 EDT

The evolving attitudes of Gen X toward evolution

As the centennial of the Scopes Monkey Trial of 1925 approaches, a new study illustrates that the attitudes of Americans in Generation X toward evolution shifted as they aged.
Wed, 10 Apr 2024 11:26:40 EDT

Brain stimulation treatment may improve depression, anxiety in older adults

A noninvasive brain stimulation treatment improved depression and anxiety symptoms among older adults in a new study.
Wed, 10 Apr 2024 11:26:38 EDT

Respiratory allergies: Newly discovered molecule plays a major role in triggering inflammation

One of the molecules responsible for triggering the inflammation that causes allergic respiratory diseases, such as asthma and allergic rhinitis, has just been discovered. This molecule, from the alarmin family, represents a therapeutic target of major interest for the treatment of allergic diseases.
Wed, 10 Apr 2024 11:26:29 EDT

AI-assisted breast-cancer screening may reduce unnecessary testing

Researchers showed that AI assistance potentially could improve breast-cancer screening by reducing the number of false positives without missing true positives.
Wed, 10 Apr 2024 11:26:21 EDT

Connecting lab-grown brain cells provides insight into how our own brains work

Researchers have developed a technique to connect lab-grown neural 'organoids' (three-dimensional developmental brain-like structures grown from human stem cells) using axonal bundles, similar to the connections between regions in the human brain. This technique allows brain networks to be better represented experimentally in the lab, and will improve understanding and studies of network-related brain disorders.
Wed, 10 Apr 2024 11:22:24 EDT

Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.
Wed, 10 Apr 2024 11:17:54 EDT

Can the bias in algorithms help us see our own?

New research shows that people recognize more of their biases in algorithms' decisions than they do in their own -- even when those decisions are the same.
Tue, 09 Apr 2024 18:40:35 EDT

The genomic architecture of inherited DNA variants

In a study that spans more than a decade, researchers have looked at generations of families in a specific population to reveal the role newly inherited DNA variants play on recessive disease traits, and in the process, they have created a population specific database revealing unique DNA information unseen in larger cohorts.
Tue, 09 Apr 2024 18:40:33 EDT

Beating back bitter taste in medicine

The bitter taste of certain drugs is a barrier to taking some medications as prescribed, especially for people who are particularly sensitive to bitter taste. A team found that the diabetes drug rosiglitazone could partially block the bitter taste of some especially bad-tasting medications. The hope is that repurposed drugs could be added in small doses to other medicines to make them less bitter and taste better, thereby encouraging compliance with bitter drug regimens.
Tue, 09 Apr 2024 17:01:52 EDT

Cardiology team performs novel heart artery repair with newly approved device

Medical researchers have performed a successful transcatheter tricuspid valve repair procedure with a groundbreaking catheter.
Tue, 09 Apr 2024 17:01:47 EDT

Nasal spray safely treats recurrent abnormal heart rhythms, clinical trial suggests

A clinical trial showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study provides real-world evidence that a wide range of patients can safely and effectively use the experimental drug, called etripamil, to treat recurrent paroxysmal supraventricular tachycardia (PSVT) episodes at home, potentially sparing them the need for repeated hospital trips for more invasive treatments.
Tue, 09 Apr 2024 15:23:24 EDT

Targeting RAS proteins may prevent relapse in Acute Myeloid Leukemia

Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line treatments.
Tue, 09 Apr 2024 12:40:36 EDT

Machine learning method reveals chromosome locations in individual cell nucleus

Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.
Tue, 09 Apr 2024 12:40:04 EDT

New consensus statement aims to improve endometriosis evaluation

A new expert consensus statement aims to improve endometriosis evaluation. Endometriosis is a common condition with substantial diagnostic delay, leading patients to experience pain, infertility, lost wages and interrupted relationships. The consensus provides recommendations for augmenting routine pelvic ultrasounds through additional maneuvers and imaging to improve diagnosis of deep endometriosis.
Tue, 09 Apr 2024 12:39:51 EDT

New technique sheds light on memory and learning

The findings may also have implications for learning and memory disorders, including Fragile X syndrome.
Tue, 09 Apr 2024 12:39:43 EDT

New atlas of mRNA variants captures inner workings of the brain

Investigators have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, neuron specialization and other brain functions.
Tue, 09 Apr 2024 12:39:37 EDT

A smarter city skyline for flood safety

With climate change and rising urbanization, the likelihood and severity of urban flooding are increasing. But not all city blocks are created equal. Researchers investigated how urban layout and building structures contribute to pedestrian safety during flooding. Based on their simulated results, the team recommends modifying building corners and protective block layouts to reduce pedestrian risk.
Tue, 09 Apr 2024 12:39:27 EDT

Bacteria in cancer unmasked

Researchers have compiled a detailed catalogue of bacteria living in cancer metastases. Having analyzed over 4000 tumors, they shed light on the diversity of these co-inhabitants and how they might interact with cancer cells and their surroundings. For example, certain bacteria were linked to a worse response to immunotherapy. This study paves the way to a better understanding of how bacteria help or hinder cancer (therapy), and how we can use this for patients' advantage.
Tue, 09 Apr 2024 12:39:22 EDT

Periostin shows promise to help fight a common form of esophageal cancer

Esophageal squamous cell carcinoma (ESCC) accounts for around 90% of esophageal cancers, especially in East Asia. New findings in indicate that periostin, or POSTN, promotes ESCC progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts (CAFs). Therefore, it may be a novel therapeutic target for treating ESCC.
Tue, 09 Apr 2024 12:39:18 EDT

Cognitive decline may be detected using network analysis, according to Concordia researchers

Researchers use network analysis to study whether it can reveal the subtle changes associated with subjective cognitive decline that cannot otherwise be detected through standard test analyses. By running a statistical analysis of data merged from two large Canadian data sets, the researchers were able to visualize the strength of relationships between the nodes among people who are classified as cognitively normal (CN), or who have diagnoses of subjective cognitive decline (SCD), mild cognitive impairment (MCI) or Alzheimer's disease (AD).
Tue, 09 Apr 2024 12:39:14 EDT

Research could unlock more precise prognoses and targeted treatments for children with cancer

Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer. A study reveals three new subgroups of the most common type of neuroblastoma, each with different genetic traits, expected outcomes, and distinguishing features that offer clues as to which treatments may be most effective.
Tue, 09 Apr 2024 12:39:11 EDT

After being insulted, writing down your feelings on paper then getting rid of it reduces anger

Researchers have discovered a simple, but effective, strategy to help people reduce their feelings of anger. Disposing of a piece of paper containing your written thoughts on the cause of your anger can effectively neutralize it. This process is like a Japanese tradition called hakidashisara, in which people write their negative thoughts on a plate then destroy it. Their findings suggest a simple and effective method of suppressing anger supported by science.
Tue, 09 Apr 2024 12:39:05 EDT

Are lab-grown brain tissues ethical? There is no no-brainer answer

Researchers offer insights into the ethical dilemmas and legal complexities surrounding brain organoids, especially those derived from human fetal tissue. Their findings advocate for thorough regulatory frameworks to ensure that scientific and medical progress in this field is conducted responsibly and ethically, with strong regulations supported by sound ethical and legal principles.
Mon, 08 Apr 2024 22:57:09 EDT

Heart disease, depression linked by inflammation

Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers have found.
Mon, 08 Apr 2024 18:38:23 EDT

The surprising connection between male infertility and family cancer risk

A study suggests families with infertile male relatives may face elevated cancer risks. Tapping into genetic data, families could help personalize cancer risk assessments.
Mon, 08 Apr 2024 18:37:47 EDT

Tiny brain bubbles carry complete codes

Scientists discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from Alzheimer's disease.
Mon, 08 Apr 2024 18:37:44 EDT

Preventive angioplasty does not improve prognosis

For heart attack patients, treating only the coronary artery that caused the infarction works just as well as preventive balloon dilation of the other coronary arteries, according to a new large study.
Mon, 08 Apr 2024 15:05:10 EDT

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